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Calcipotriol
🥰Excellent
Catalog No. T14856Cas No. 112965-21-6
Alias MC 903, Calcipotriene
Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.
Calcipotriol
🥰Excellent
Purity: 99.07%
Catalog No. T14856Alias MC 903, CalcipotrieneCas No. 112965-21-6
Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $52 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $133 | In Stock | |
| 50 mg | $237 | In Stock | |
| 100 mg | $432 | In Stock |
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View MoreInhibitors Related to "Calcipotriol"
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Calcipotriol monohydrate
TQ0244147657-22-5
Calcipotriol monohydrate is an analog of Vitamin D3 with a high affinity for the vitamin D receptor. Calcipotriol monohydrate can be used for studies about psoriasis.
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Ercalcitriol
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TQ021660133-18-8
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24, 25-Dihydroxy VD2
24,25-Dihydroxy vitamin D2
T1910758050-55-8
24, 25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a metabolite of vitamin D2, which is the isomer of vitamin D present in the body as 25-hydroxyvitamin D. PF-04957325 is used in the study of autoimmune encephalomyelitis.
- $698
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Purity:99.07%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor. |
| In vitro | Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM), when NHEK cells are not stimulated with IL-17A or IL-22. The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20, and 40 nM in a dose-dependent manner [1]. Treatment of natural killer (NK) cells with drugs modulate their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of Calcipotriol, 1,25(OH)2D3, and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation [2]. |
| In vivo | Compare with placebo, the weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002). Survival is equally distributed between the groups. One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived [3]. |
| Alias | MC 903, Calcipotriene |
| Molecular Weight | 412.6 |
| Formula | C27H40O3 |
| Cas No. | 112965-21-6 |
| Smiles | C[C@H](\C=C\[C@@H](O)C1CC1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |
| Relative Density. | 1.12g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (242.37 mM) Ethanol: 50 mg/mL (121.18 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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