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5-A-RU hydrochloride

Catalog No. T10165L CAS 134452-11-2

Synonyms: 5-Amino-6-(D-ribitylamino)uracil hydrochloride

5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) is an intermediate of bacterial riboflavin that activates mucosal-associated invariant T cells (MAIT).5-A-RU is used in the study of breast and prostate cancer.

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5-A-RU hydrochloride, CAS 134452-11-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 1,320.00
5 mg	In stock	$ 2,650.00
10 mg	In stock	$ 3,570.00
25 mg	In stock	$ 5,280.00
50 mg	In stock	$ 7,160.00
100 mg	In stock	Inquiry

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Purity: 100%

Biological Description

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Description	5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) is an intermediate of bacterial riboflavin that activates mucosal-associated invariant T cells (MAIT).5-A-RU is used in the study of breast and prostate cancer.
In vitro	5-A-RU hydrochloride (2 μM) can be used to stimulate human MAIT cells and produce MR1 tetramers for identification of human and mouse MAIT cells[1].
In vivo	When 5-A-RU hydrochloride (100 nM; i.p.; 18 hours) and MeG were mixed ex tempore prior to in vivo injection, MAIT cells in iVα19 Cα−/−-Tg mice were activated[2].

Synonyms	5-Amino-6-(D-ribitylamino)uracil hydrochloride
Molecular Weight	312.71
Formula	C9H17ClN4O6
CAS No.	134452-11-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (319.78 mM), Sonification and heating are recommended.

References and Literature

1. Li K,et al. Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). PLoS One. 2018 Feb 5;13(2):e0191837. 2. Soudais C,et al. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells. J Immunol. 2015 May 15;194(10):4641-9. 3. Mak JY, et al. Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nat Commun. 2017 Mar 8;8:14599.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

5-A-RU hydrochloride 134452-11-2 Others 5 A RU hydrochloride 5ARU hydrochloride 5-A-RU Hydrochloride 5-Amino-6-(D-ribitylamino)uracil hydrochloride inhibitor inhibit

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