Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 313.00 | |
10 mg | In stock | $ 537.00 | |
25 mg | In stock | $ 869.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,590.00 | |
500 mg | In stock | $ 3,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 345.00 |
Description | 6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM). |
Targets&IC50 | UCHL3:236 µM , UCHL1:0.23 µM |
In vitro | 6RK73 (5 µM; 1-3 hours) treatment displays strong inhibition of the TGFβ-induced pSMAD2 and pSMAD3, and a decrease of TβRI and total SMAD protein levels in MDA-MB-436 cells. 6RK73 (5 µM; 24-48 hours) results in migration significantly slower than the DMSO control group in MDA-MB-436 cells[1]. |
In vivo | 6RK73 displays a potent inhibition of breast cancer extravasation in zebrafish[1]. |
Cell Research | Cell Line: MDA-MB-436 cells Concentration: 5 µM Incubation Time: 24, 48 hours |
Molecular Weight | 307.37 |
Formula | C13H17N5O2S |
CAS No. | 1895050-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (366 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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6RK73 1895050-66-4 Others 6RK-73 inhibitor inhibit