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7,4'-Di-O-methylapigenin
🥰Excellent
Catalog No. T5690Cas No. 5128-44-9
Alias 4',7-DIMETHOXY-5-HYDROXYFLAVONE
7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
7,4'-Di-O-methylapigenin
🥰Excellent
Purity: 99.4%
Catalog No. T5690Alias 4',7-DIMETHOXY-5-HYDROXYFLAVONECas No. 5128-44-9
7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $39 | In Stock | |
| 5 mg | $84 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $462 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $94 | In Stock |
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Purity:99.4%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) can inhibit α-glucosidase and α-amylase enzymes and enhance 2-NBDG uptake in L6 cells, it has hypolipidemic effect on mouse pre-adipocyte (3T3L1) cell lines. |
| In vitro | Antioxidant activity in terms of TRP (196.03 μg/mg GAE), DPPH assay (IC50-173.09 μg/mL), hydroxyl radical scavenging assay (IC50-20.42 μg/mL), inhibiting LDL oxidation (IC50-51.99 μg/mL) and to enhance SOD activity (25.3 %) was higher in ethyl acetate extract (EAP). Phenolic and flavonoid content was measured and showed a positive correlation with antioxidant activity. Presence of 4',7-DIMETHOXY-5-HYDROXYFLAVONE and piperine (Pip) in EAP was determined by HPTLC analysis and was isolated. 4',7-DIMETHOXY-5-HYDROXYFLAVONE inhibited α-glucosidase and α-amylase enzymes and enhanced 2-NBDG uptake in L6 cells. Hypolipidemic effect of 4',7-DIMETHOXY-5-HYDROXYFLAVONE on mouse pre-adipocyte (3T3L1) cell lines also showed a dose dependent reduction on lipid droplet content and effective concentration range was determined as 1-2.5 μg/mL. Suggested that Piper longum fruits can provide a natural source of antioxidants with antidiabetic and anti obesity potential. |
| Cell Research | Solvent extracts from Piper longum fruits using hexane, ethyl acetate, methanol, 70 % methanol-water were taken and 4',7-DIMETHOXY-5-HYDROXYFLAVONE was isolated from ethyl acetate extract. Antioxidant activity, glucose uptake potential and adipocyte differentiation assay was performed with extract and pure compound. |
| Alias | 4',7-DIMETHOXY-5-HYDROXYFLAVONE |
| Molecular Weight | 298.29 |
| Formula | C17H14O5 |
| Cas No. | 5128-44-9 |
| Smiles | COc1ccc(cc1)-c1cc(=O)c2c(O)cc(OC)cc2o1 |
| Relative Density. | 1.321g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 7 mg/mL (23.47 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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