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7-Hydroxyaristolochic acid A

🥰Excellent
Catalog No. TN1004Cas No. 79185-75-4

7-Hydroxyaristolochic acid A is a natural derivative of aristolochic acid. Aristolochic acid is nephrotoxic and carcinogenic, inhibits APE1/Nrf2/HO-1 axis-induced oxidative stress and apoptosis leading to nephrotoxicity, and induces apoptosis in NRK-52E cells via COX-2 and PGE2.

7-Hydroxyaristolochic acid A

7-Hydroxyaristolochic acid A

🥰Excellent
Catalog No. TN1004Cas No. 79185-75-4
7-Hydroxyaristolochic acid A is a natural derivative of aristolochic acid. Aristolochic acid is nephrotoxic and carcinogenic, inhibits APE1/Nrf2/HO-1 axis-induced oxidative stress and apoptosis leading to nephrotoxicity, and induces apoptosis in NRK-52E cells via COX-2 and PGE2.
Pack SizePriceAvailabilityQuantity
1 mg$50 In Stock
5 mg$112 In Stock
10 mg$183 In Stock
25 mg$310 In Stock
50 mg$465 In Stock
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Product Introduction

Bioactivity
Description
7-Hydroxyaristolochic acid A is a natural derivative of aristolochic acid. Aristolochic acid is nephrotoxic and carcinogenic, inhibits APE1/Nrf2/HO-1 axis-induced oxidative stress and apoptosis leading to nephrotoxicity, and induces apoptosis in NRK-52E cells via COX-2 and PGE2.
Chemical Properties
Molecular Weight357.27
FormulaC17H11NO8
Cas No.79185-75-4
SmilesO=C(C1=CC2=C(C3=C4C=CC(O)=C(C4=CC([N+]([O-])=O)=C13)OC)OCO2)O
Relative Density.1.656g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (223.92 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7990 mL13.9950 mL27.9900 mL139.9502 mL
5 mM0.5598 mL2.7990 mL5.5980 mL27.9900 mL
10 mM0.2799 mL1.3995 mL2.7990 mL13.9950 mL
20 mM0.1400 mL0.6998 mL1.3995 mL6.9975 mL
50 mM0.0560 mL0.2799 mL0.5598 mL2.7990 mL
100 mM0.0280 mL0.1400 mL0.2799 mL1.3995 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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