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7-Ketocholesterol

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Purity:99.46%

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COA HNMR HPLC

7-Ketocholesterol

Catalog No. TN6715Cas No. 566-28-9

7-Ketocholesterol is a metabolite of Cholesterol

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Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$73	In Stock
25 mg	$158	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Related Compound Libraries of "7-Ketocholesterol"

Product Introduction

Bioactivity

Description

7-Ketocholesterol is a metabolite of Cholesterol

In vivo

7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation.?7KC induces a dose-dependent loss of cell viability and an increase in apoptosis and necrosis in the endothelial cells.?A relocalization of the tight junction proteins, zonula occludens-1 (ZO-1) and claudin-5, towards the nucleus of the cells was also observed.?These effects were significantly attenuated by ET. In addition, 7KC induces marked increases in the mRNA expression of pro-inflammatory cytokines, IL-1β IL-6, IL-8, TNF-α and cyclooxygenase-2 (COX2), as well as COX2 enzymatic activity, and these were significantly reduced by ET.

Chemical Properties

Molecular Weight	400.65
Formula	C27H44O2
Cas No.	566-28-9

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 4.01mg (10 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4959 mL	12.4797 mL	24.9594 mL	124.7972 mL
5 mM	0.4992 mL	2.4959 mL	4.9919 mL	24.9594 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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