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A-9758

Catalog No. T10210 CAS 2055271-22-0

Purity 98.00% Datasheet

A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.

A-9758, CAS 2055271-22-0

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Purity 98.00%

Datasheet MSDS

Biological Description

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Description	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.
Targets&IC50	RORγt :ic50 5 nM, RORα :ic50 73 nM, RORβ :ic50 1370 nM,

Molecular Weight	527.36
Formula	C25H23Cl2F3N2O3
CAS No.	2055271-22-0

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Gauld S, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046.

Related Products

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TAK-828F Xylan Vimirogant AZD-0284 RORγt Inverse agonist 8 A-9758 S18-000003 FM26

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