Shopping Cart

Remove All
Your shopping cart is currently empty

ACT-678689

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

Catalog No. T14119Cas No. 1783256-96-1

Select Batch

Purity:99.46%

Resource Download

COA HPLC LCMS HNMR

ACT-678689

Catalog No. T14119Cas No. 1783256-96-1

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$163	In Stock
10 mg	$248	In Stock
25 mg	$413	In Stock
50 mg	$572	In Stock
100 mg	$768	In Stock
200 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "ACT-678689"

Product Introduction

Bioactivity

Description	ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
Targets&IC50	TPH:8 nM
In vitro	TPH consists of two isoforms, TPH1 and TPH2. TPH1 is primarily found in peripheral tissues, especially the enterochromaffin cells (EC) in the gut, and is vital for the synthesis of 5HT, which is stored in the circulating blood platelets[1]. Conversely, TPH2 is predominantly expressed in neuronal cell types within the central nervous system (CNS).
Alias	Compound Example 1.53.4

Chemical Properties

Molecular Weight	565.04
Formula	C₂₃H₂₂ClFN₆O₄S₂
Cas No.	1783256-96-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 120 mg/mL (212.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7698 mL	8.8489 mL	17.6979 mL	88.4893 mL
5 mM	0.3540 mL	1.7698 mL	3.5396 mL	17.6979 mL
10 mM	0.1770 mL	0.8849 mL	1.7698 mL	8.8489 mL
20 mM	0.0885 mL	0.4424 mL	0.8849 mL	4.4245 mL
50 mM	0.0354 mL	0.1770 mL	0.3540 mL	1.7698 mL
100 mM	0.0177 mL	0.0885 mL	0.1770 mL	0.8849 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc