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ARD-266
Catalog No. T13552
ARD-266 is a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader, effectively inducing AR protein degradation in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s: 0.2-1 nM).
ARD-266
Catalog No. T13552
ARD-266 is a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader, effectively inducing AR protein degradation in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s: 0.2-1 nM).
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| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ARD-266 is a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader, effectively inducing AR protein degradation in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s: 0.2-1 nM). |
| In vitro | ARD-266 (Compound 11; 100 nM; 1-24 hours; LNCaP and VCaP cells) reduces AR protein levels within 3 hours, achieving near-complete AR elimination after 6 hours in LNCaP cells. ARD-266 (1-10000 nM; 24 hours; LNCaP cells) also suppresses PSA, TMPRSS2, and FKBP5 gene expression in a dose-dependent manner, reducing mRNA levels by over 50% at 10 nM in LNCaP cells. |
| Molecular Weight | 915.51 |
| Formula | C52H59ClN6O7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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