Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.
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Description | Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. |
In vitro | Aclacinomycin A can efficiently penetrate living cells, enabling in situ fluorescence visualization. A mere 15-minute exposure to a 10 μM concentration of Aclacinomycin A suffices for distinct fluorescence detection across various cultured cell lines. This treatment also leads to approximately 20% cell mortality (or near mortality) [1]. Furthermore, Aclacinomycin A has been shown to effectively stimulate the inclusion of exon 7 into SMN2 transcripts, both from the endogenous gene in type I SMA fibroblasts and from an SMN2 minigene in NSC34 motor neuron cell lines [2]. |
Synonyms | Aclarubicin hydrochloride |
Molecular Weight | 848.33 |
Formula | C42H54ClNO15 |
CAS No. | 75443-99-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (147.35 mM)
You can also refer to dose conversion for different animals. More
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Aclacinomycin A hydrochloride 75443-99-1 Proteases/Proteasome Ubiquitination Proteasome Aclacinomycin A Hydrochloride Aclarubicin Hydrochloride Aclarubicin hydrochloride inhibitor inhibit