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Atosiban

Catalog No. T4996   CAS 90779-69-4
Synonyms: RWJ22164, RW22164

Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.

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Atosiban Chemical Structure
Atosiban, CAS 90779-69-4
Pack Size Availability Price/USD Quantity
5 mg 5 days $ 62.00
10 mg 5 days $ 92.00
50 mg 5 days $ 216.00
100 mg 5 days $ 315.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Synonyms RWJ22164, RW22164
Molecular Weight 994.19
Formula C43H67N11O12S2
CAS No. 90779-69-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.67 mg/mL (16.77 mM), sonification is recommended.

DMSO: 16.67 mg/mL (16.77 mM)

TargetMolReferences and Literature

1. Akerlund M, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504. 2. Sanu O, et al. Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther Clin Risk Manag. 2010 Apr 26;6:191-9.

Related Products

Related compounds with same targets
Pro8-Oxytocin TFA L-371,257 Carbetocin acetate PF-06655075 PF-06655075 TFA Pro8-Oxytocin (Val3,Pro8)-Oxytocin LIT-001

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Keywords

Atosiban 90779-69-4 Endocrinology/Hormones GPCR/G Protein Oxytocin Receptor Vasopressin Receptor nonapeptide desamino-oxytocin OXTR vasopressin tocolytic RWJ 22164 Ca2+ Preterm Inhibitor maternal-fetal inhibit RWJ22164 RW-22164 RWJ-22164 oxytocin RW22164 RW 22164 inhibitor

 

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