Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 5 days | $ 62.00 | |
10 mg | 5 days | $ 92.00 | |
50 mg | 5 days | $ 216.00 | |
100 mg | 5 days | $ 315.00 |
Description | Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence. |
Synonyms | RWJ22164, RW22164 |
Molecular Weight | 994.19 |
Formula | C43H67N11O12S2 |
CAS No. | 90779-69-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 16.67 mg/mL (16.77 mM), sonification is recommended.
DMSO: 16.67 mg/mL (16.77 mM)
You can also refer to dose conversion for different animals. More
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Atosiban 90779-69-4 Endocrinology/Hormones GPCR/G Protein Oxytocin Receptor Vasopressin Receptor nonapeptide desamino-oxytocin OXTR vasopressin tocolytic RWJ 22164 Ca2+ Preterm Inhibitor maternal-fetal inhibit RWJ22164 RW-22164 RWJ-22164 oxytocin RW22164 RW 22164 inhibitor