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Nelivaptan
🥰Excellent
Catalog No. T28153Cas No. 439687-69-1
Alias SSR149415, SR-149415, SR 149415
Nelivaptan (SR 149415) is a vasopressin V1b receptor antagonist that can eliminate CHS-induced GE damage and inhibit [3H]AVP binding in a competitive manner.
Nelivaptan
🥰Excellent
Purity: 98.39%
Catalog No. T28153Alias SSR149415, SR-149415, SR 149415Cas No. 439687-69-1
Nelivaptan (SR 149415) is a vasopressin V1b receptor antagonist that can eliminate CHS-induced GE damage and inhibit [3H]AVP binding in a competitive manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $153 | In Stock | |
| 10 mg | $220 | In Stock | |
| 25 mg | $367 | In Stock | |
| 50 mg | $545 | In Stock | |
| 100 mg | $785 | In Stock | |
| 500 mg | $1,630 | In Stock |
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Atosiban acetate
RWJ22164, RW22164, Atosiban acetate (90779-69-4 free base)
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Terlipressin Acetate
Terlipressin acetate anhydrous
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d[Leu4,Lys8]-VP acetate
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Purity:98.39%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nelivaptan (SR 149415) is a vasopressin V1b receptor antagonist that can eliminate CHS-induced GE damage and inhibit [3H]AVP binding in a competitive manner. |
| In vitro | METHODS: Nelivaptan (SR 149415) (1.25 nM, 2.5 nM and 5 nM) was used to treat In-R1-G9 pancreatic model cells, and the inhibitory effect of Nelivaptan on the specific binding of [3H]AVP (radiolabeled vasopressin) was detected. RESULTS As the concentration of Nelivaptan5 increased, the Kd value (dissociation constant) under control conditions showed a dose-dependent decrease, which indicated that Nelivaptan inhibited the binding of [3H]AVP in a competitive manner, and the Ki value of Nelivaptan (inhibition constant) is 1.61 ± 0.17 nM. [1] |
| In vivo | METHODS: Animals in the male Wistar rat administration group and the Nelivaptan (SR 149415) group were intraperitoneally injected with drug (1ml/kg, 5% DMSO, 95% normal saline) or Nelivaptan dissolved in the drug (1ml/kg; stock solution concentration 5mg/kg) , the rats were placed in a high temperature environment of 38°C for 60 minutes, and the body weight and rectal temperature were measured before and immediately after treatment. RESULTS Nelivaptan treatment reduced intracranial V1bR levels. [2] METHODS: Nelivaptan was injected with DMSO as solvent at a dose of 1 nmol/rat (icv) with a volume of 5µl. The rats were monitored under basal non-stress (NS) conditions, acute stress (AS), CHS and CHeS. Changes in hypothalamic OXT and AVP release under conditions. RESULTS Nelivaptan could eliminate CHS-induced GE damage. [3] |
| Alias | SSR149415, SR-149415, SR 149415 |
| Molecular Weight | 630.11 |
| Formula | C30H32ClN3O8S |
| Cas No. | 439687-69-1 |
| Smiles | O=C1[C@](C=2C(N1S(=O)(=O)C3=C(OC)C=C(OC)C=C3)=CC=C(Cl)C2)(N4[C@H](C(N(C)C)=O)C[C@@H](O)C4)C5=C(OC)C=CC=C5 |
| Relative Density. | 1.414 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (79.35 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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