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BAY-678

Catalog No. T10473 CAS 675103-36-3

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

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BAY-678, CAS 675103-36-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 378.00
100 mg	In stock	$ 562.00
500 mg	In stock	$ 1,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 98.25%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).
Targets&IC50	HNE:20 nM, MNE:700 nM(Ki)
In vitro	BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium.[2] The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE.[1]
In vivo	BAY-678 reveals significant efficacy in preclinical models of ALI and lung emphysema. Additionally, BAY-678 has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.[2]

Molecular Weight	400.35
Formula	C20H15F3N4O2
CAS No.	675103-36-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (224.8 mM)

Ethanol: 4.3 mg/mL (10.7 mM)

References and Literature

1. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. 2. von Nussbaum F, et al. Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4370-81. 3. BAY-678 Selective chemical probe for Human Neutrophil Elastase.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Covalent Inhibitor Library

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Keywords

BAY-678 675103-36-3 Others BAY 678 BAY678 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.