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CCT365623 hydrochloride

CCT365623 hydrochloride
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
Catalog No. T10719Cas No. 2126136-98-7
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CCT365623 hydrochloride

Catalog No. T10719Cas No. 2126136-98-7
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
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Pack SizePriceAvailabilityQuantity
25 mg$1,8201-2 weeks
50 mg$2,3801-2 weeks
100 mg$3,1001-2 weeks
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Product Introduction

Bioactivity
Description
CCT365623 hydrochloride is an orally active lysyl oxidase (LOX) inhibitor with an IC50 of 0.89 μM and suppresses EGFR (pY1068) and AKT phosphorylation induced by EGF.
Targets&IC50
LOX:0.89 μM
In vitro
CCT365623 inhibits LOX at approximately 5 μM in the biosensor system. CCT365623 (0-40 μM) decreases surface EGFR protein levels in a concentration-dependent manner, disrupts HTRA1 multimerization, activates [TGFβ1] signaling, suppresses MATN2 expression, and reduces EGFR surface retention and signaling. At 5 μM, CCT365623 decreases pY1068 EGFR, pAKT, and MATN2 protein levels, while increasing pSMAD2 protein levels.
In vivo
CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cells. CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%.
Chemical Properties
Molecular Weight443.99
FormulaC18H18ClNO4S3
Cas No.2126136-98-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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