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CJ-42794

🥰Excellent
Catalog No. T14975Cas No. 847728-01-2
Alias CJ-042794

CJ-42794 (CJ-042794) is a selective antagonist of the prostaglandin E receptor subtype 4 (EP4), inhibiting [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It exhibits a binding affinity that is at least 200-fold more selective for the human EP4 receptor than for other human EP receptor subtypes (EP1, EP2, and EP3) (IC50: 8.5 (pKi)).

CJ-42794

CJ-42794

🥰Excellent
Purity: 99.49%
Catalog No. T14975Alias CJ-042794Cas No. 847728-01-2
CJ-42794 (CJ-042794) is a selective antagonist of the prostaglandin E receptor subtype 4 (EP4), inhibiting [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It exhibits a binding affinity that is at least 200-fold more selective for the human EP4 receptor than for other human EP receptor subtypes (EP1, EP2, and EP3) (IC50: 8.5 (pKi)).
Pack SizePriceAvailabilityQuantity
5 mg$32In Stock
10 mg$50In Stock
25 mg$98In Stock
1 mL x 10 mM (in DMSO)$51In Stock
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Purity:99.49%
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Product Introduction

Bioactivity
Description
CJ-42794 (CJ-042794) is a selective antagonist of the prostaglandin E receptor subtype 4 (EP4), inhibiting [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It exhibits a binding affinity that is at least 200-fold more selective for the human EP4 receptor than for other human EP receptor subtypes (EP1, EP2, and EP3) (IC50: 8.5 (pKi)).
In vitro
CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor (mean pA2: 8.6). CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner [1].
In vivo
CJ-42794 significantly delays ulcer healing in rats and mice and these responses were both attenuated by coadministration of CJ-42794 [2].
AliasCJ-042794
Chemical Properties
Molecular Weight413.83
FormulaC22H17ClFNO4
Cas No.847728-01-2
SmilesC[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O
Relative Density.1.347 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 28 mg/mL (67.66 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4165 mL12.0823 mL24.1645 mL120.8226 mL
5 mM0.4833 mL2.4165 mL4.8329 mL24.1645 mL
10 mM0.2416 mL1.2082 mL2.4165 mL12.0823 mL
20 mM0.1208 mL0.6041 mL1.2082 mL6.0411 mL
50 mM0.0483 mL0.2416 mL0.4833 mL2.4165 mL

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Keywords

tumor necrosis factor αprostaglandin E2Progesterone ReceptorNR3C3Inhibitorinhibithuman whole bloodgastric ulcersCJ-42794CJ42794CJ042794CJ 42794CJ 042794cAMP
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