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CP-868388 free base

Name: CP-868388 free base
Brand: TargetMol
SKU: T31083
Price: 195 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T31083Cas No. 702681-67-2

Alias UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388

CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.

CP-868388 free base

😃Good

Purity: 99.84%

Catalog No. T31083Alias UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388Cas No. 702681-67-2

CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.

Pack Size	Price	Availability	Quantity
1 mg	$52	5 days
5 mg	Inquiry	In Stock

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Purity:99.84%

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COA LCMS HNMR ORP

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.
Targets&IC50	HepG2 cells:18 nM (EC50), PPARγ (human):3.47 μM (Ki), SRC-1:4.7 nM (EC50), PPARα (human):10.8 nM (Ki)
In vitro	The compound CP-868388, at concentrations ranging from 0-1 mM, exhibits strong and dose-dependent recruitment of SRC-1, with an EC50 of 4.7 nM, as well as the PGC-1α peptide[1]. Additionally, CP-868388 demonstrates potent and selective transcriptional activation of PPARα, showing an EC50 of 18 nM in HepG2 cells[1].
In vivo	In male B6/CBF1J mice, treatment with CP-868388 (oral gavage; once daily; for 2 days) at doses ranging from 0-3 mg/kg results in a robust and highly significant decrease in circulating plasma triglycerides. The dose-dependent effect is observed, with the highest efficacy achieved at the 3.0 mg/kg dose, leading to a reduction of approximately 50% in triglyceride levels[1].
Alias	UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388

Chemical Properties

Molecular Weight	439.54
Formula	C₂₆H₃₃NO₅
Cas No.	702681-67-2
Smiles	CC(C)c1ccc(COC(=O)N2CCC[C@H](C2)c2cccc(OC(C)(C)C(O)=O)c2)cc1
Relative Density.	1.161 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (227.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2751 mL	11.3755 mL	22.7511 mL	113.7553 mL
5 mM	0.4550 mL	2.2751 mL	4.5502 mL	22.7511 mL
10 mM	0.2275 mL	1.1376 mL	2.2751 mL	11.3755 mL
20 mM	0.1138 mL	0.5688 mL	1.1376 mL	5.6878 mL
50 mM	0.0455 mL	0.2275 mL	0.4550 mL	2.2751 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	1.1376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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