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CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $52 | 5 days | |
5 mg | Inquiry | In Stock |
Description | CP-868388 free base (CP-868388) is an orally active, potent and selective PPARα agonist with hypolipidemic and anti-inflammatory activity for the study of dyslipidemia. |
Targets&IC50 | PPARγ (human):3.47 μM (Ki), HepG2 cells:18 nM (EC50), SRC-1:4.7 nM (EC50), PPARα (human):10.8 nM (Ki) |
In vitro | The compound CP-868388, at concentrations ranging from 0-1 mM, exhibits strong and dose-dependent recruitment of SRC-1, with an EC50 of 4.7 nM, as well as the PGC-1α peptide[1]. Additionally, CP-868388 demonstrates potent and selective transcriptional activation of PPARα, showing an EC50 of 18 nM in HepG2 cells[1]. |
In vivo | In male B6/CBF1J mice, treatment with CP-868388 (oral gavage; once daily; for 2 days) at doses ranging from 0-3 mg/kg results in a robust and highly significant decrease in circulating plasma triglycerides. The dose-dependent effect is observed, with the highest efficacy achieved at the 3.0 mg/kg dose, leading to a reduction of approximately 50% in triglyceride levels[1]. |
Alias | UNII-999KY5ZIGB, CP-868388, CP868388, CP 868388, (-)-CP-868388 |
Molecular Weight | 439.54 |
Formula | C26H33NO5 |
Cas No. | 702681-67-2 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (227.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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