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DPA-714

DPA-714 is a high-affinity translocator protein (TSPO) ligand (Ki=7 nM) designed with a fluorine atom, allowing labeling with fluorine-18 for in vivo imaging via positron emission tomography. [18F]DPA-714 successfully enables specific imaging of inflammation in various neuroinflammation models and a brain tumor model.

Catalog No. T15162Cas No. 958233-07-3

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Purity:99.52%

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COA HNMR HPLC LCMS

DPA-714

Catalog No. T15162Cas No. 958233-07-3

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Pack Size	Price	Availability
1 mg	$92	In Stock
5 mg	$228	In Stock
10 mg	$372	In Stock
25 mg	$629	In Stock
50 mg	$896	In Stock
100 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Product Introduction

Bioactivity

Description	DPA-714 is a high-affinity translocator protein (TSPO) ligand (Ki=7 nM) designed with a fluorine atom, allowing labeling with fluorine-18 for in vivo imaging via positron emission tomography. [18F]DPA-714 successfully enables specific imaging of inflammation in various neuroinflammation models and a brain tumor model.
Targets&IC50	TSPO:(ki)7 nM

Chemical Properties

Molecular Weight	398.47
Formula	C₂₂H₂₇FN₄O₂
Cas No.	958233-07-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 41.67 mg/mL (104.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5096 mL	12.5480 mL	25.0960 mL	125.4800 mL
5 mM	0.5019 mL	2.5096 mL	5.0192 mL	25.0960 mL
10 mM	0.2510 mL	1.2548 mL	2.5096 mL	12.5480 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2740 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5096 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

inhibitDPA 714InhibitorDPA-714DPA714