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Edaglitazone
Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity.
Catalog No. T27239Cas No. 213411-83-7
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Edaglitazone
Catalog No. T27239Alias R-483, RO-2052349-602, RO-2052349-000, Edaglitazone sodium, BM-13.1258Cas No. 213411-83-7
Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $358 | 35 days |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity. |
| Targets&IC50 | PPARα:1053 nM (EC50), PPARγ:35.6 nM (EC50) |
| In vitro | METHODS: To elucidate the mechanism of the antiplatelet effect of edaglitazone, platelet cAMP levels were assessed using edaglitazone (3, 6, and 12 μM), Consistent with the aggregation assay, RESULTS: Edaglitazone increased platelet cAMP levels in a concentration-dependent manner, suggesting that its antiplatelet effect is partly mediated by the regulation of cAMP levels. [1] |
| Alias | R-483, RO-2052349-602, RO-2052349-000, Edaglitazone sodium, BM-13.1258 |
| Molecular Weight | 464.56 |
| Formula | C24H20N2O4S2 |
| Cas No. | 213411-83-7 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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