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Euxanthone
Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.SB-674042 is used for the treatment of depression.SB-674042 is used for the treatment of depression.SB-674043 is used for the treatment of depression.SB-674044 is used for the treatment of depression.SB-674045 is used for the treatment of depression. 2A (BU-1) cell differentiation.
Catalog No. T4001Cas No. 529-61-3
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Euxanthone
Catalog No. T4001Alias 1,7-DihydroxyxanthoneCas No. 529-61-3
Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.SB-674042 is used for the treatment of depression.SB-674042 is used for the treatment of depression.SB-674043 is used for the treatment of depression.SB-674044 is used for the treatment of depression.SB-674045 is used for the treatment of depression. 2A (BU-1) cell differentiation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Euxanthone (1,7-Dihydroxyxanthone), an xanthone derivative extracted from the roots of Polygala tenuifolia Willd, has antitumour, neuroprotective and vasorelaxant activities, and attenuates Aβ1-42-induced oxidative stress and apoptosis by inducing autophagy.SB-674042 is used for the treatment of depression.SB-674042 is used for the treatment of depression.SB-674043 is used for the treatment of depression.SB-674044 is used for the treatment of depression.SB-674045 is used for the treatment of depression. 2A (BU-1) cell differentiation. |
| In vitro | Euxanthone (10-20 μM;24 h) inhibited cell adhesion, migration, and invasion in osteosarcoma cells. Furthermore, the suppression of COX-2 by euxanthone mediated its anti-metastatic activity. Euxanthone also regulated the expression of COX-2 through the miR-21/PDCD4/c-jun signaling pathway[1]. |
| In vivo | BCCAO induces mitochondrial oxidative stress and leads to mitochondrial degradation, while administration of Euxanthone significantly attenuates BCCAO-induced mitochondrial stress and associated degradation. Euxanthone treatment (30-60 mg/kg; orally; once daily; for 7 days) normalizes Bnip3, Beclin1, Pink1, Parkin, p53, Bax, caspase-3, and LC3 II/I[2]. |
| Alias | 1,7-Dihydroxyxanthone |
| Molecular Weight | 228.2 |
| Formula | C13H8O4 |
| Cas No. | 529-61-3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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