Shopping Cart
- Remove All
Your shopping cart is currently empty
FR194738
Catalog No. T11320Cas No. 204067-52-7
FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.
FR194738
Catalog No. T11320Cas No. 204067-52-7
FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,840 | 1-2 weeks | |
| 50 mg | $2,390 | 1-2 weeks | |
| 100 mg | $3,400 | 1-2 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "FR194738"
Dehydroacetic acid sodium
Sodium dehydroacetate
T224274418-26-2
Dehydroacetic acid sodium (Sodium dehydroacetate) is the sodium salt of dehydroacetic acid, a bactericide and fungicide that is commonly used as a food preservative. Dehydroacetic acid sodium is a preservative that is used in the formulation of personal care products and cosmetics in order to extend the shelf-life by preventing microbial contamination.
- $31
Size
QTY
Geraniol
T5665106-24-1
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
- $46
Size
QTY
Potassium gluconate
Potassium D-gluconate, K-Iao, Kaon elixir, Kaon, Kalium-beta, Kalium Gluconate, HSDB 3165
T20198299-27-4
Potassium gluconate (Potassium D-gluconate) is an oxidizing carboxylic acid with oral activity and chelating properties with bactericidal activity.
- $29
Size
QTY
Chitosan (MW 150000)
Poly(D-glucosamine), Deacetylated chitin, Chitosan
T17159012-76-4
Chitosan (MW 150000) (Deacetylated chitin) is a linear polysaccharide made up of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine.
- $42
Size
QTY
Lauryl betaine
n-Dodecyl-N, 2-(Dodecyldimethylammonio)acetate
TF0109683-10-3
Lauryl betaine (n-Dodecyl-N) has antifungal activity and inhibits Malassezia spp. Lauryl betaine is used as a surfactant and emulsifier and is commonly used in the skin care industry.
- $30
Size
QTY
2-Butyl-1,2-benzisothiazolin-3-one
2-butylbenzo[d]isothiazol-3(2H)-one
T777004299-07-4
2-Butyl-1,2-benzisothiazolin-3-one is an orally available antimicrobial agent with antimicrobial activity commonly used in the pharmaceutical profession and food processing.
- $195
Size
QTY
Paclobutrazol
2R,3R-Paclobutrazol, (R,R)-paclobutrazol, (2R,3R)-Paclobutrazol
T3827376738-62-0
Paclobutrazol ((R,R)-paclobutrazol) is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins.1,2It also has antifungal activities.3PBZ, which is transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants.1,4,5PBZ is typically used to support research on the role of gibberellins in plant biology.
- $34
Size
QTY
Veratraldehyde
3,4-Dimethoxybenzaldehyde
T5657120-14-9
Veratraldehyde (3,4-Dimethoxybenzaldehyde) has antifungal activity .It is found in Cymbopogon javanensis.
- $29
Size
QTY
Tebuconazole
T17022107534-96-3
Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).
- $50
Size
QTY
Potassium sorbate
Sorbic acid potassium salt, Potassium 2,4-hexadienoate
T480724634-61-5
Potassium sorbate (Sorbic acid potassium salt) acts as a potential antifungal agent when used in conjunction with polyethylene films. It also used as a corrosion inhibitor via corrosion mitigation.
- $30
Size
QTY
Sorbic acid
T8019110-44-1
Sorbic acid is a natural product that inhibits various bacteria, including sporeformers,
- $30
Size
QTY
Ammonium Chloride
T6475512125-02-9
Ammonium chloride acts as a small molecule autophagy inhibitor.Ammonium chloride is a pH-regulating, heteropolar compound that can cause intracellular alkalosis and metabolic acidosis, thereby affecting enzyme activity and influencing processes in biological systems.Ammonium chloride has potential antimicrobial activity. Ammonium Chloride has potential antimicrobial activity and prevents training-induced improvement in mitochondrial respiratory function in male rat flounder muscle.
- $55
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates. |
| Targets&IC50 | SE (HepG2 cell homogenates):9.8 nM |
| In vitro | FR194738 inhibits cholesterol biosynthesis in HepG2 cells (IC50 = 2.1 nM)[1]. FR194738 concentration-dependently inhibits hamster liver microsomal squalene epoxidase activity (IC50 = 14 nM)[2]. FR194738 inhibits the incorporation of [14C]acetate in intact HepG2 cells into free cholesterol (IC50 = 4.9 nM) and cholesteryl ester (IC50 = 8.0 nM) in a concentration-dependent manner. FR194738 induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene[3]. |
| In vivo | FR194738 (32 and 100 mg/kg) reduces the serum levels of total, non HDL and HDL cholesterol, and triglyceride and increases HMG-CoA reductase activity by 1.3-fold at a dose of 32 mg/kg[2]. |
| Molecular Weight | 476.11 |
| Formula | C27H38ClNO2S |
| Cas No. | 204067-52-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (420.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy FR194738 | purchase FR194738 | FR194738 cost | order FR194738 | FR194738 chemical structure | FR194738 in vivo | FR194738 in vitro | FR194738 formula | FR194738 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.