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FR194738 free base

FR194738 free base
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Purity:99.65%
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FR194738 free base

Catalog No. T11321Cas No. 204067-45-8
FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. 
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Pack SizePriceAvailabilityQuantity
1 mg$139In Stock
5 mg$298In Stock
10 mg$433In Stock
25 mg$678In Stock
50 mg$912In Stock
100 mg$1,180In Stock
1 mL x 10 mM (in DMSO)$328In Stock
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Product Introduction

Bioactivity
Description
FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. 
Targets&IC50
SE (HepG2 cell homogenates):9.8 nM
In vitro
FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM[2]. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM). FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene[3].
In vivo
FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride. In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold[2].
Chemical Properties
Molecular Weight439.65
FormulaC27H37NO2S
Cas No.204067-45-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (204.7 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2745 mL11.3727 mL22.7454 mL113.7268 mL
5 mM0.4549 mL2.2745 mL4.5491 mL22.7454 mL
10 mM0.2275 mL1.1373 mL2.2745 mL11.3727 mL
20 mM0.1137 mL0.5686 mL1.1373 mL5.6863 mL
50 mM0.0455 mL0.2275 mL0.4549 mL2.2745 mL
100 mM0.0227 mL0.1137 mL0.2275 mL1.1373 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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