Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 148.00 | |
5 mg | 5 days | $ 247.00 | |
10 mg | 5 days | $ 413.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 272.00 |
Description | GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux. |
Targets&IC50 | KIF15:0.82 μM, ULK1:PIC50=6.37 |
In vitro | GW406108X were acting upon ULK1 and autophagy without affecting mTOR or AMPK activity as shown by monitoring ULK1 pS758 (mTOR site) or pS556 (AMPK site) levels[1]. |
Synonyms | GW108X |
Molecular Weight | 400.21 |
Formula | C20H11Cl2NO4 |
CAS No. | 1644443-92-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL(112.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GW406108X 1644443-92-4 Autophagy Cytoskeletal Signaling Kinesin ATP flux GW-406108X competitive Inhibitor U2OS inhibit GW108X ULK autophagic cells Unc-51 like kinase inhibitor