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Ganoderic acid C1

Catalog No. TN1660   CAS 95311-97-0

Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.

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Ganoderic acid C1 Chemical Structure
Ganoderic acid C1, CAS 95311-97-0
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Biological Description
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Storage & Solubility Information
Description Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
In vitro Ganoderic acid C1 was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α± and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α± production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α±, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to the downregulation of the NF-κB signaling pathway[1].
Molecular Weight 514.65
Formula C30H42O7
CAS No. 95311-97-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL (93.26 mM)

TargetMolReferences and Literature

1. Liu C, et al. Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling. Inflamm Bowel Dis. 2015 Aug;21(8):1918-25. 2. Changda Liu, et al. Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int Immunopharmacol. 2015 Aug;27(2):224-31.

Related compound libraries

This product is contained In the following compound libraries:
Rare Natural Compound Library Reprogramming Compound Library Antiparasitic Natural Product Library Osteogenesis Compound Library Neural Regeneration Compound Library Anti-Fibrosis Compound Library Cytokine Inhibitor Library

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Keywords

Ganoderic acid C1 95311-97-0 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Immunology/Inflammation MAPK Microbiology/Virology Neuroscience NF-Κb Proteases/Proteasome NF-κB TNF IL Receptor DNA/RNA Synthesis COX HIV Protease Ganoderic acid C-1 Inhibitor inhibit Ganoderic acid C 1 inhibitor

 

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