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HSK0935
Catalog No. T15505Cas No. 1638851-44-1
Alias HSK-0935, HSK 0935
HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
HSK0935
Catalog No. T15505Alias HSK-0935, HSK 0935Cas No. 1638851-44-1
HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,420 | 6-8 weeks | |
| 50 mg | $1,850 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities. |
| Targets&IC50 | SGLT2:1.3 nM |
| In vitro | HSK0935 shows excellent hSGLT2 inhibition of 1.3 nM. HSK0935 displays a high hSGLT1/hSGLT2 selectivity of 843-fold[1]. |
| In vivo | In a 28-day repeat-dose toxicology study conducted on beagle dogs, HSK0935 was found to be well-tolerated at doses up to 300 mg/kg, without causing any deaths or severe adverse effects. Additionally, treatment with HSK0935 at doses of 1, 3, and 10 mg/kg resulted in significant urinary glucose excretion in Sprague-Dawley (SD) rats, and had an even greater effect on urinary glucose excretion in Rhesus monkeys[1]. |
| Alias | HSK-0935, HSK 0935 |
| Molecular Weight | 436.88 |
| Formula | C22H25ClO7 |
| Cas No. | 1638851-44-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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