Shopping Cart
- Remove All
Your shopping cart is currently empty
Ertugliflozin L-pyroglutamic acid
Catalog No. T15244Cas No. 1210344-83-4
Alias PF-04971729 L-pyroglutamic acid
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM, suitable for studies on the treatment of type 2 diabetes mellitus.
Ertugliflozin L-pyroglutamic acid
Catalog No. T15244Alias PF-04971729 L-pyroglutamic acidCas No. 1210344-83-4
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM, suitable for studies on the treatment of type 2 diabetes mellitus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $39 | In Stock | |
| 10 mg | $55 | In Stock | |
| 25 mg | $82 | In Stock | |
| 50 mg | $97 | In Stock | |
| 100 mg | $143 | In Stock | |
| 200 mg | $209 | In Stock | |
| 500 mg | $358 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Ertugliflozin L-pyroglutamic acid"
Empagliflozin
Cited
BI 10773
T1766864070-44-0
Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes.
- $39
Size
QTY
CitedPhlorizin Cited
Phloridzin, NSC 2833, Floridzin
T292260-81-1
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
- $46
Size
QTY
CitedPhlorizin Cited
Phloridzin, NSC 2833, Floridzin
T292260-81-1
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
- $46
Size
QTY
CitedPhlorizin Cited
Phloridzin, NSC 2833, Floridzin
T292260-81-1
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
- $46
Size
QTY
CitedDapagliflozin ((2S)-1,2-propanediol, hydrate)
Dapagliflozin propanediol monohydrate, BMS-512148 (2S)-1,2-propanediol, hydrate
T4460960404-48-2
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.
- $37
Size
QTY
Dapagliflozin Cited
BMS-512148
T2389461432-26-8
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
- $42
Size
QTY
CitedDapagliflozin Cited
BMS-512148
T2389461432-26-8
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.
- $42
Size
QTY
CitedErtugliflozin
PF-04971729, MK-8835
T49991210344-57-2
PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
- $45
Size
QTY
Ipragliflozin
ASP1941
T2385761423-87-4
Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
- $52
Size
QTY
Canagliflozin Cited
TA 7284, JNJ 28431754AAA, JNJ 28431754, JNJ 24831754ZAE
T1782842133-18-0
Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).
- $43
Size
QTY
CitedSelect Batch
Purity:99.84%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM, suitable for studies on the treatment of type 2 diabetes mellitus. |
| Targets&IC50 | SGLT2 (human):0.877 nM |
| In vitro | Ertugliflozin L-pyroglutamic acid demonstrated >2000-fold selectivity for SGLT2 over SGLT[2]. |
| In vivo | The oral administration of Ertugliflozin L-pyroglutamic to rats acid showed concentration-dependent glucosuria[2]. |
| Alias | PF-04971729 L-pyroglutamic acid |
| Molecular Weight | 566 |
| Formula | C27H32ClNO10 |
| Cas No. | 1210344-83-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (220.85 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Ertugliflozin L-pyroglutamic acid | purchase Ertugliflozin L-pyroglutamic acid | Ertugliflozin L-pyroglutamic acid cost | order Ertugliflozin L-pyroglutamic acid | Ertugliflozin L-pyroglutamic acid chemical structure | Ertugliflozin L-pyroglutamic acid in vivo | Ertugliflozin L-pyroglutamic acid in vitro | Ertugliflozin L-pyroglutamic acid formula | Ertugliflozin L-pyroglutamic acid molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.