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Phlorizin

Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .

Catalog No. T2922Cas No. 60-81-1

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Purity:99.76%

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COA HNMR HPLC

Phlorizin

Catalog No. T2922Cas No. 60-81-1

Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .

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Pack Size	Price	Availability
500 mg	$46	In Stock
1 g	$55	In Stock
5 g	$197	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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Product Introduction

Bioactivity

Description	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
Targets&IC50	SGLT1 (human):300 nM(Ki), SGLT2 (human):39 nM(Ki)
In vivo	In the treatment of diabetes, obesity, and stress-induced hyperglycemia, Phlorizin exerts its therapeutic effects by inhibiting the sodium-glucose cotransporters located in the proximal renal tubules and the intestinal mucosa. This inhibition results in renal glucosuria and impedes the absorption of glucose in the intestines.
Alias	Floridzin, NSC 2833, Phloridzin

Chemical Properties

Molecular Weight	436.41
Formula	C₂₁H₂₄O₁₀
Cas No.	60-81-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 43.6 mg/mL (100 mM)

DMSO: 60 mg/mL (137.49 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2914 mL	11.4571 mL	22.9142 mL	114.5712 mL
5 mM	0.4583 mL	2.2914 mL	4.5828 mL	22.9142 mL
10 mM	0.2291 mL	1.1457 mL	2.2914 mL	11.4571 mL
20 mM	0.1146 mL	0.5729 mL	1.1457 mL	5.7286 mL
50 mM	0.0458 mL	0.2291 mL	0.4583 mL	2.2914 mL
100 mM	0.0229 mL	0.1146 mL	0.2291 mL	1.1457 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc