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Phlorizin
🥰Excellent
Catalog No. T2922Cas No. 60-81-1
Alias Phloridzin, NSC 2833, Floridzin
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
Phlorizin
🥰Excellent
Purity: 99.76%
Catalog No. T2922Alias Phloridzin, NSC 2833, FloridzinCas No. 60-81-1
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $46 | In Stock | |
| 1 g | $55 | In Stock | |
| 5 g | $197 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $51 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . |
| Targets&IC50 | SGLT2 (human):39 nM(Ki), SGLT1 (human):300 nM(Ki) |
| In vivo | In the treatment of diabetes, obesity, and stress-induced hyperglycemia, Phlorizin exerts its therapeutic effects by inhibiting the sodium-glucose cotransporters located in the proximal renal tubules and the intestinal mucosa. This inhibition results in renal glucosuria and impedes the absorption of glucose in the intestines. |
| Alias | Phloridzin, NSC 2833, Floridzin |
| Molecular Weight | 436.41 |
| Formula | C21H24O10 |
| Cas No. | 60-81-1 |
| Smiles | C(CCC1=CC=C(O)C=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2O |
| Relative Density. | 1.3178 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 43.6 mg/mL (100 mM) DMSO: 60 mg/mL (137.49 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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