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Product Introduction

Bioactivity

Description	Hypaconine, a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp., exhibits strong cardiac activity.
In vitro	Among them, eleven compounds exhibited cardiac activity, with average rate of amplitude increase in the range of 16-118%. Compound 7, mesaconine (17), Hypaconine (25), and beiwutinine (26) exhibited strong cardiac activities relative to the reference drug.

Chemical Properties

Molecular Weight	469.57
Formula	C₂₄H₃₉NO₈
Cas No.	63238-68-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (117.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1296 mL	10.6480 mL	21.2961 mL	106.4804 mL
5 mM	0.4259 mL	2.1296 mL	4.2592 mL	21.2961 mL
10 mM	0.2130 mL	1.0648 mL	2.1296 mL	10.6480 mL
20 mM	0.1065 mL	0.5324 mL	1.0648 mL	5.3240 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL	2.1296 mL
100 mM	0.0213 mL	0.1065 mL	0.2130 mL	1.0648 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HypaconineInhibitorcardiacinhibit