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IGS-1.76

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Purity:98.76%

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COA HNMR HPLC

IGS-1.76

Catalog No. T8784Cas No. 313480-47-6

IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a.

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Pack Size	Price	Availability
1 mg	$98	In Stock
5 mg	$249	In Stock
10 mg	$416	In Stock
25 mg	$692	In Stock
50 mg	$985	In Stock
100 mg	$1,330	In Stock
500 mg	$2,660	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock

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Product Introduction

Bioactivity

Description	IGS-1.76 exhibits pronounced affinity towards hNCS-1 and effectively modulates the interaction between hNCS-1 and Ric8a. Moreover, IGS-1.76 proficiently inhibits the complex formed by human NCS-1 and Ric8a.
In vitro	IGS-1.76, which efficiently inhibits the human NCS-1/Ric8a complex with improved binding potency.

Chemical Properties

Molecular Weight	358.46
Formula	C22H18N2OS
Cas No.	313480-47-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (62.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7897 mL	13.9486 mL	27.8971 mL	139.4856 mL
5 mM	0.5579 mL	2.7897 mL	5.5794 mL	27.8971 mL
10 mM	0.2790 mL	1.3949 mL	2.7897 mL	13.9486 mL
20 mM	0.1395 mL	0.6974 mL	1.3949 mL	6.9743 mL
50 mM	0.0558 mL	0.2790 mL	0.5579 mL	2.7897 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc