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KD-3010

Catalog No. T11747 CAS 934760-92-6

KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.

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KD-3010, CAS 934760-92-6

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,820.00
50 mg	8-10 weeks	$ 2,380.00
100 mg	8-10 weeks	$ 3,100.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Purity: 99.61%

Biological Description

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Description

KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.

In vivo

To investigate the potential benefits of PPARδ agonists in experimental liver fibrosis, mice are orally treated with a PPARδ agonist, KD-3010, or the well-validated PPARδ agonist GW501516. In liver fibrosis induced by carbon tetrachloride (CCl4) or bile duct ligation (BDL), KD-3010, but not GW501516, demonstrates hepatoprotective and antifibrotic effects. The induction of liver injury is achieved through repeated injections of CCl4, and mice are orally administered vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 on a daily basis. Control mice injected with oil do not exhibit liver damage. Liver injury, characterized by hepatocyte death and inflammation, is observed in the group treated with vehicle or GW501516 and injected with CCl4 based on H&E-stained liver sections, but this injury is markedly reduced in the KD-3010-treated group[1].

Molecular Weight	670.72
Formula	C30H33F3N2O8S2
CAS No.	934760-92-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Iwaisako K, et al. Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1369-76.

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Keywords

KD-3010 934760-92-6 DNA Damage/DNA Repair Metabolism PPAR KD 3010 KD3010 inhibitor inhibit

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