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KF 13218

Catalog No. T11755 CAS 127654-03-9

KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.

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KF 13218, CAS 127654-03-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
Targets&IC50	TXB2:5.3 nM
In vitro	KF 13218 effectively suppresses arachidonic acid-triggered thromboxane B2 synthesis in human intact platelets, showing a notable inhibitory concentration (IC50) of 5.3±1.3 nM. This potency is approximately fivefold greater against intact platelets than against the microsomal enzyme, indicating a significant specificity. Remarkably, the compound's ability to inhibit thromboxane synthase within platelets remains even after the extracellular substance is eliminated. Furthermore, KF 13218 demonstrates inhibition of both human and bovine platelet thromboxane synthase with IC50 values of 27±5.8 nM and 36±6.9 nM, respectively, without affecting cyclooxygenase or 5-lipoxygenase at doses up to 100 μM nor antagonizing thromboxane A2/prostaglandin H2 receptors.
In vivo	KF 13218, when administered orally at a dosage of 0.1 mg/kg, effectively prevents mortality caused by sodium arachidonate in rabbits. Additionally, dosages ranging from 0.03 mg/kg to 3 mg/kg in rats lead to a dose-dependent inhibition of thromboxane B2 production in serum, with the effect maintained for up to 72 hours.

Molecular Weight	336.38
Formula	C20H20N2O3
CAS No.	127654-03-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

KF 13218 127654-03-9 Chromatin/Epigenetic Histone Demethylase KF-13218 KF13218 inhibitor inhibit

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