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KPT185
🥰Excellent
Catalog No. T2425Cas No. 1333151-73-7
Alias KPT-185, KPT 185
KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
KPT185
🥰Excellent
Purity: 98%
Catalog No. T2425Alias KPT-185, KPT 185Cas No. 1333151-73-7
KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest. |
| Targets&IC50 | CRM1:100-500nM |
| In vivo | In leukemia cells (IC50=100 nM-500 nM), KPT-185 significantly inhibited cell proliferation. In AML cell lines and primary AML mother cells, KPT-185 was able to arrest the cell cycle and induce apoptosis. In pancreatic cancer cells, KPT-185 inhibited cell proliferation and induced apoptosis, but KPT-185 did not affect the growth of human pancreatic ductal epithelial cells. |
| Cell Research | Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference) |
| Alias | KPT-185, KPT 185 |
| Molecular Weight | 355.31 |
| Formula | C16H16F3N3O3 |
| Cas No. | 1333151-73-7 |
| Smiles | COc1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)OC(C)C)n1 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: <1 mg/mL DMSO: 66 mg/mL (185.8 mM) Ethanol: 66 mg/mL (185.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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