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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $10,568 | 10-14 weeks | |
50 mg | $13,728 | 10-14 weeks | |
100 mg | $17,839 | 10-14 weeks |
Description | KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death. |
In vitro | KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro. Treating human islets with KU-32 for 24 hours displays no toxicity. KU-32 improves cellular viability by blocking apoptosis, with a minimum of 2-day exposure. When preincubate in KU-32, isolated human islets release more glucose-stimulated insulin [1] [2]. |
In vivo | Administered with KU-32 (10 weeks; diabetic BKS-db/db mice) do not display any obvious changes in blood glucose and insulin levels, despite having greater insulin staining/beta cells in the pancreas compared to untreated BKS db/db mice[1]. |
Molecular Weight | 407.41 |
Formula | C20H25NO8 |
Cas No. | 956498-70-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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