Shopping Cart
- Remove All
Your shopping cart is currently empty
KU-32
Catalog No. T15671Cas No. 956498-70-7
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
KU-32
Catalog No. T15671Cas No. 956498-70-7
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $10,568 | 10-14 weeks | |
| 50 mg | $13,728 | 10-14 weeks | |
| 100 mg | $17,839 | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "KU-32"
Palmitic acid
Cited
Hexadecoic acid, hexadecanoic acid, Cetylic acid
T290857-10-3
Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms. Palmitic acid has antitumor activity.
- $48
Size
QTY
CitedTamoxifen
Cited
Z-Tamoxifen, trans-Tamoxifen, ICI47699, ICI 46474
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
- $39
Size
QTY
CitedPaeoniflorin
Peoniflorin
T223023180-57-6
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
- $41
Size
QTY
Rifabutin
LM-427, Ansamycin
T150172559-06-9
Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.
- $42
Size
QTY
Teprenone
Tetraprenylacetone, Geranylgeranylacetone
T50086809-52-5
Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).
- $46
Size
QTY
Ethoxyquin
Santoquin, Santoflex, Quinol
T075691-53-2
Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
- $29
Size
QTY
Elesclomol Cited
STA-4783
T6170488832-69-5
Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.
- $34
Size
QTY
CitedTamoxifen Citrate
Tamoxifen Z-isomer citrate, ICI 46474 Citrate, ICI 46474
T083554965-24-1
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
- $48
Size
QTY
SNX0723
SNX- 0723, SNX 0723
T288241073969-18-2In house
SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM.
- $82
Size
QTY
SNX2112 Cited
SNX-2112, SNX 2112, PF 04928473
T6305908112-43-6
SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.
- $41
Size
QTY
CitedGanetespib Cited
STA-9090
T2309888216-25-9
Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90), exhibiting potential antineoplastic activity.
- $61
Size
QTY
CitedDN401
DN-401, DN 401
T271932135749-60-7In house
DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.
- $195
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death. |
| In vitro | KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro. Treating human islets with KU-32 for 24 hours displays no toxicity. KU-32 improves cellular viability by blocking apoptosis, with a minimum of 2-day exposure. When preincubate in KU-32, isolated human islets release more glucose-stimulated insulin [1] [2]. |
| In vivo | Administered with KU-32 (10 weeks; diabetic BKS-db/db mice) do not display any obvious changes in blood glucose and insulin levels, despite having greater insulin staining/beta cells in the pancreas compared to untreated BKS db/db mice[1]. |
| Molecular Weight | 407.41 |
| Formula | C20H25NO8 |
| Cas No. | 956498-70-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy KU-32 | purchase KU-32 | KU-32 cost | order KU-32 | KU-32 chemical structure | KU-32 in vivo | KU-32 in vitro | KU-32 formula | KU-32 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.