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KU-32

KU-32
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
Catalog No. T15671Cas No. 956498-70-7

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KU-32

Catalog No. T15671Cas No. 956498-70-7

KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$10,56810-14 weeks
50 mg$13,72810-14 weeks
100 mg$17,83910-14 weeks
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Product Introduction

Bioactivity
Description
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
In vitro
KU-32 protects against glucose-induced death of embryonic DRG (dorsal root ganglia) neurons cultured for 3 days in vitro. Treating human islets with KU-32 for 24 hours displays no toxicity. KU-32 improves cellular viability by blocking apoptosis, with a minimum of 2-day exposure. When preincubate in KU-32, isolated human islets release more glucose-stimulated insulin [1] [2].
In vivo
Administered with KU-32 (10 weeks; diabetic BKS-db/db mice) do not display any obvious changes in blood glucose and insulin levels, despite having greater insulin staining/beta cells in the pancreas compared to untreated BKS db/db mice[1].
Chemical Properties
Molecular Weight407.41
FormulaC20H25NO8
Cas No.956498-70-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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