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LDC7559

LDC7559
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
Catalog No. T11828Cas No. 2407782-01-6
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Purity:99.47%
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LDC7559

Catalog No. T11828Cas No. 2407782-01-6
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$72In Stock
5 mg$197In Stock
10 mg$328In Stock
25 mg$558In Stock
50 mg$788In Stock
100 mg$1,120In Stock
1 mL x 10 mM (in DMSO)$226In Stock
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Product Introduction

Bioactivity
Description
LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
In vitro
LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells[3].
Chemical Properties
Molecular Weight349.38
FormulaC20H19N3O3
Cas No.2407782-01-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (271.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8622 mL14.3111 mL28.6221 mL143.1107 mL
5 mM0.5724 mL2.8622 mL5.7244 mL28.6221 mL
10 mM0.2862 mL1.4311 mL2.8622 mL14.3111 mL
20 mM0.1431 mL0.7156 mL1.4311 mL7.1555 mL
50 mM0.0572 mL0.2862 mL0.5724 mL2.8622 mL
100 mM0.0286 mL0.1431 mL0.2862 mL1.4311 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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