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LMPTP INHIBITOR 1 hydrochloride
🥰Excellent
Catalog No. T4491Cas No. 2310135-38-5
Alias LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.
LMPTP INHIBITOR 1 hydrochloride
🥰Excellent
Purity: 99.63%
Catalog No. T4491Alias LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))Cas No. 2310135-38-5
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 245 € | In Stock | |
| 5 mg | 609 € | In Stock | |
| 10 mg | 867 € | In Stock | |
| 25 mg | 1.301 € | In Stock | |
| 50 mg | 1.757 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 696 € | In Stock |
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Purity:99.63%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A. |
| Targets&IC50 | LMPTPA:0.8 μM |
| In vitro | LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1]. |
| In vivo | LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1]. |
| Alias | LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) |
| Molecular Weight | 481.07 |
| Formula | C28H37ClN4O |
| Cas No. | 2310135-38-5 |
| Smiles | CCN(C(c1ccc(c(cc2NCCCN3CCCCC3)nc4c2cccc4)cc1)=O)CC.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (18.71 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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