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LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $258 | In Stock | |
5 mg | $642 | In Stock | |
10 mg | $913 | In Stock | |
25 mg | $1,370 | In Stock | |
50 mg | $1,850 | In Stock | |
1 mL x 10 mM (in DMSO) | $733 | In Stock |
Description | LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A. |
Targets&IC50 | LMPTPA:0.8 μM |
In vitro | LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1]. |
In vivo | LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1]. |
Alias | LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)) |
Molecular Weight | 481.07 |
Formula | C28H37ClN4O |
Cas No. | 2310135-38-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 9 mg/mL (18.71 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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