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LMPTP INHIBITOR 1 hydrochloride

Catalog No. T4491Cas No. 2310135-38-5
Alias LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.

LMPTP INHIBITOR 1 hydrochloride

LMPTP INHIBITOR 1 hydrochloride

Purity: 99.63%
Catalog No. T4491Alias LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))Cas No. 2310135-38-5
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.
Pack SizePriceAvailabilityQuantity
1 mg$258In Stock
5 mg$642In Stock
10 mg$913In Stock
25 mg$1,370In Stock
50 mg$1,850In Stock
1 mL x 10 mM (in DMSO)$733In Stock
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Purity:99.63%
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Product Introduction

Bioactivity
Description
LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.
Targets&IC50
LMPTPA:0.8 μM
In vitro
LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes [1].
In vivo
LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight [1].
AliasLMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))
Chemical Properties
Molecular Weight481.07
FormulaC28H37ClN4O
Cas No.2310135-38-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (18.71 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0787 mL10.3935 mL20.7870 mL103.9350 mL
5 mM0.4157 mL2.0787 mL4.1574 mL20.7870 mL
10 mM0.2079 mL1.0393 mL2.0787 mL10.3935 mL

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