Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 147.00 | |
25 mg | 6-8 weeks | $ 730.00 | |
50 mg | 6-8 weeks | $ 949.00 | |
100 mg | 6-8 weeks | $ 1,430.00 |
Description | ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
Targets&IC50 | K2P2.1 (TREK-1, HEK293 cells):9.7 μM(EC50), K2P2.1 (TREK-1):(EC50)36.3 μM |
In vitro | ML67-33 activates K2P channels and mutants. It has an EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively. |
Molecular Weight | 374.27 |
Formula | C18H17Cl2N5 |
CAS No. | 1443290-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ML67-33 1443290-89-8 Microbiology/Virology Proteases/Proteasome HIV Protease ML67 33 ML6733 ML-67-33 inhibitor inhibit