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MRS 1754

Catalog No. T16140 CAS 264622-58-4

MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.

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MRS 1754, CAS 264622-58-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.
Targets&IC50	A2B:1.45±0.21 nM(Ki, human)
In vitro	The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM. The most effective displacer of [3H]MRS 1754 binding is MRS 1754. .

Molecular Weight	486.52
Formula	C26H26N6O4
CAS No.	264622-58-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15 mg/mL (30.83 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ji X, et al. [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MRS 1754 264622-58-4 GPCR/G Protein Neuroscience Adenosine Receptor MRS-1754 Inhibitor P1 receptor MRS1754 inhibit inhibitor

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