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CLZ-8
🥰Excellent
Catalog No. T16030Cas No. 678158-55-9
Alias Mcl1-IN-8, CLZ8, CLZ 8
CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
CLZ-8
🥰Excellent
Purity: 99.85%
Catalog No. T16030Alias Mcl1-IN-8, CLZ8, CLZ 8Cas No. 678158-55-9
CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $43 | In Stock |
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Purity:99.85%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CLZ-8 (Mcl1-IN-8) is an orally active inhibitor of Mcl-1-PUMA (p53 up-regulated mediator of apoptosis) with radioprotective properties.CLZ-8 ameliorates radiation-induced HUVEC cell damage and reduces apoptosis counts, and inhibits radiation-induced overexpression of PUMA. |
| Targets&IC50 | MCL1:0.3 μM (Ki) |
| In vitro | In DLD-1 cells or HUVEC cells, CLZ-8 (0-160 μM; 48 hours for DLD-1 or 24 hours for HUVECs) significantly inhibits PUMA-dependent apoptosis with an IC50 of 38.93 ± 0.91 μM and attenuates radiation-induced apoptosis[1]. |
| In vivo | In 6-8 week-old male BALB/c mice, CLZ-8 (100, 200, and 400 mg/kg; intragastric administration, once, 30 minutes prior to irradiation) increases the survival rate of irradiated mice[2]. |
| Alias | Mcl1-IN-8, CLZ8, CLZ 8 |
| Molecular Weight | 393.5 |
| Formula | C22H23N3O2S |
| Cas No. | 678158-55-9 |
| Smiles | OCCN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(cc1)-c1ccccc1 |
| Relative Density. | 1.27 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (101.65 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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