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Menadione
Catalog No. T0449Cas No. 58-27-5
Alias Vitamin K3
Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Menadione
Catalog No. T0449Alias Vitamin K3Cas No. 58-27-5
Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $65 | In Stock | |
| 1 g | $98 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.08%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. |
| In vivo | In AR4-2J cells, Menadione (1-20 mM) inhibits cell proliferation in a dose- and time-dependent manner. In the RALA255-10G rat liver cell line, Menadione activates extracellular signal-regulated kinase and c-Jun N-terminal kinase. Furthermore, Menadione suppresses multidrug-resistant leukemia cell lines (IC50=13.5 mM) and primary leukemia cell lines (IC50=18 mM). At 100 mM, Menadione induces DNA fragmentation, leading to rapid cell death. Additionally, in normal pancreatic acinar cells, Menadione inhibits mitochondrial Ca(2+) uptake. |
| Alias | Vitamin K3 |
| Molecular Weight | 172.18 |
| Formula | C11H8O2 |
| Cas No. | 58-27-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 32 mg/mL (185.9 mM) DMSO: 55 mg/mL (319.43 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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