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N-Acetyl-L-cysteine ethyl ester

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Catalog No. T41285Cas No. 59587-09-6
Alias N-Acetylcysteine ethyl ester, NACET

N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.

N-Acetyl-L-cysteine ethyl ester

N-Acetyl-L-cysteine ethyl ester

🥰Excellent
Catalog No. T41285Alias N-Acetylcysteine ethyl ester, NACETCas No. 59587-09-6
N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.
Pack SizePriceAvailabilityQuantity
10 mg$40In Stock
25 mg$71In Stock
50 mg$113In Stock
100 mg$198In Stock
500 mg$515In Stock
1 mL x 10 mM (in DMSO)$44In Stock
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Product Introduction

Bioactivity
Description
N-Acetyl-L-cysteine ethyl ester (NACET) is a derivative of the amino acid L-cysteine. NACET has been shown to exhibit diverse biochemical and physiological effects, including inhibition of protein synthesis, inhibition of DNA replication, and induction of apoptosis. Additionally, it has demonstrated anti-inflammatory, antioxidant, and anti-cancer activity.
In vitro
Under concomitant oxidative stress induced by 2 mM H2O2, N-Acetyl-L-cysteine ethyl ester (NACET) showed strong and significant protective effect on RPE cells when the concentration was 0.4 mM. Moreover, NACET treatment also resulted in an enhanced protective effect when RPE cells were stressed by the organic ROS generator peroxide tert-Butyl hydroperoxide (t-BOOH).NACET significantly increased both intracellular GSH and cysteine at 0.2 and 1 mM concentrations, respectively, as well as extracellular total GSH[2].
AliasN-Acetylcysteine ethyl ester, NACET
Chemical Properties
Molecular Weight191.25
FormulaC7H13NO3S
Cas No.59587-09-6
SmilesCCOC(=O)[C@H](CS)NC(C)=O
Relative Density.1.138 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45.0 mg/mL (235.3 mM), Sonication is recommended.
H2O: 90.0 mg/mL (470.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.2288 mL26.1438 mL52.2876 mL261.4379 mL
5 mM1.0458 mL5.2288 mL10.4575 mL52.2876 mL
10 mM0.5229 mL2.6144 mL5.2288 mL26.1438 mL
20 mM0.2614 mL1.3072 mL2.6144 mL13.0719 mL
50 mM0.1046 mL0.5229 mL1.0458 mL5.2288 mL
100 mM0.0523 mL0.2614 mL0.5229 mL2.6144 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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