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Nanchangmycin

Catalog No. T6601 CAS 65101-87-3

Synonyms: Nanchangmycin A

Nanchangmycin, a polyether antibiotic, is similar to the structure of dianemycin. It is very potent against the broad spectrum of harmful nematodes and insects but not for mammals and plants.

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Nanchangmycin, CAS 65101-87-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nanchangmycin, a polyether antibiotic, is similar to the structure of dianemycin. It is very potent against the broad spectrum of harmful nematodes and insects but not for mammals and plants.
In vitro	Nanchangmycin resists gram-positive bacteria.
In vivo	Nanchangmycin, a growth promoter in poultry, cures coccidiosis in chickens. Nanchangmycin, a bacterially-derived natural product, blocks ZIKV and DENV infection potently in diverse cell types.
Kinase Assay	Histone deacetylase activity:For PCI-34051 characterization, measurements are performed in a reaction volume of 100 μL using 96-well assay plates in a fluorescence plate reader. For each isozyme. The HDAC protein in reaction buffer (50 mM HEPES, 100 mM KCl, 0.001% Tween-20, 5% dimethyl sulfoxide, pH7.4, supplemented with bovine serum albumin at concentrations of 0-0.05%) is mixed with PCI-34051 at various concentrations and allowed to incubate for 15 min. Trypsin is added to a final concentration of 50 nM, and acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methyl coumarin is added to a final concentration of 25-100 μM to initiate the reaction. After a 30 min lag time, the fluorescence is measured over a 30 min time frame using an excitation wavelength of 335 nm and a detection wavelength of 460 nm. The increase in fluorescence with time is used as the measure of the reaction rate.
Cell Research	5×10E3 U2OS cells were plated in 25ul media per well in 384-well plates and cultured for 24 hours. Add 50 nl of Nanchangmycin, which is 0.7uM dissolved in 0.2% DMSO, to each well incubating for 1 hour.

Synonyms	Nanchangmycin A
Molecular Weight	889.1
Formula	C48H80O13
CAS No.	65101-87-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 88.9 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Liu T, et al. Chem Biol. 2008, 15(5), 449-458.

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nanchangmycin 65101-87-3 Microbiology/Virology Antibacterial Antibiotic Inhibitor Nanchangmycin A inhibit Bacterial inhibitor

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