Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ. |
In vitro | OP-1074 as a pure antiestrogen and a selective ER degrader (PA-SERD) that is efficacious in shrinking tumors in a tamoxifen-resistant xenograft model. Biochemical and crystal structure analyses reveal a structure activity relationship implicating the importance of a stereospecific methyl on the pyrrolidine side chain of OP-1074, particularly on helix 12. |
Molecular Weight | 457.56 |
Formula | C29H31NO4 |
CAS No. | 1443752-76-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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OP-1074 1443752-76-8 Endocrinology/Hormones Estrogen/progestogen Receptor OP1074 OP 1074 inhibitor inhibit