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Panaxydol

Catalog No. TN2039 CAS 72800-72-7

Panaxydol has anti-cancer activity, can inhibit the growth and Apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.

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Panaxydol, CAS 72800-72-7

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Purity: 98%

Biological Description

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Description

Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.

In vitro

Cell growth inhibition of panaxynol and Panaxydol were determined by trypan blue dye exclusion assays. Apoptosis of cells was revealed by morphological observation, analysis for nuclear DNA distribution and by annexin V-FITC/ PI staining using flow cytometry. It was found that panaxynol and Panaxydol markedly inhibited proliferation of HL60 cells in a time- and dose-dependent manner via an apoptotic pathway. In concern with these ndings, Western blot analysis showed proteolytic activation of PKCα′, caspase-3 activation and cleavage of poly (ADP [adenosine diphosphate]-ribose) polymerase in HL60 cells treated by panaxynol and Panaxydol[1]

Molecular Weight	260.37
Formula	C17H24O2
CAS No.	72800-72-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol.Molecules. 2011 Jun 29;16(7):5561-73.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Panaxydol 72800-72-7 GPCR/G Protein MAPK p38 MAPK cAMP JNK Inhibitor inhibitor inhibit

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