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Polyoxyethylene stearate

Catalog No. T16561 CAS 9004-99-3

Synonyms: POES

Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.

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Polyoxyethylene stearate Chemical Structure

Polyoxyethylene stearate, CAS 9004-99-3

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500 mg	In stock	$ 30.00
1 g	In stock	$ 42.00
5 g	In stock	$ 75.00

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Purity: polymer

Biological Description

Chemical Properties

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Description	Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
In vitro	Polyoxyethylene stearate modulates P-gp ATPase activity in a concentration-dependent manner, reducing P-gp mediated efflux, notably enhancing the efficacy of substances like vinblastine sulfate by limiting their expulsion from cells. This compound is also recommended to augment the radiolabelled 7H12 Middlebrook TB media, significantly promoting mycobacterial growth in the BACTEC rapid culture system. Its effectiveness extends across various mycobacterial species beyond M. tuberculosis. Specifically, at concentrations of 100 or 150 μg/mL, polyoxyethylene 40 stearate substantially increases the cytotoxicity of vinblastine to K562/ADR cells. Moreover, polyoxyethylene (50) stearate markedly boosts mycobacterial growth rates and decreases detection times in cultures, illustrating its broad potential in enhancing antimicrobial and chemotherapeutic treatments.
In vivo	In the combination of polyoxyethylene 40 stearate and vinblastine, there is a significant reduction in both the average tumor volume and weight compared to the vinblastine group alone. The tumor growth inhibition rate markedly increases from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). Furthermore, polyoxyethylene stearate shows potential as a pharmaceutical excipient to enhance the oral bioavailability of drugs that are substrates for P-glycoprotein (P-gp) and certain cytochrome P450 (CYP) isoforms [2][3].

Synonyms	POES
Molecular Weight	N/A
Formula	C20H40O3
CAS No.	9004-99-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (136.97 mM)

References and Literature

1. Cutler RR, et al. The effect of polyoxyethylene stearate (POES) on the growth of mycobacteria in radiometric 7H12 Middlebrook TB medium. Tubercle. 1987 Sep;68(3):209-20. 2. Zhu S, et al. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450. Eur J Pharm Sci. 2009 Jul 12;37(5):573-80. 3. Luo L, et al. Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate. AAPS J. 2007 Oct 5;9(3):E329-35.

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Keywords

Polyoxyethylene stearate 9004-99-3 Membrane transporter/Ion channel Microbiology/Virology Neuroscience Antibacterial P-gp POES Cluster of differentiation 243 CD243 Bacterial Polyoxyethylene Stearate MDR1 Inhibitor Pgp P-glycoprotein Multidrug resistance protein 1 ABCB1 inhibit inhibitor

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