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Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 1.444 € | 6-8 weeks | |
50 mg | 1.881 € | 6-8 weeks | |
100 mg | 2.375 € | 6-8 weeks |
Description | Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis. |
Targets&IC50 | RhoA:(kd)0.4 uM |
In vitro | Rhosin induces decreased size and reduced number of mammospheres in MCF7 cells. Rhosin dose-dependently decreases RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50: ~30-50 μM) [1]. |
Molecular Weight | 358.4 |
Formula | C20H18N6O |
Cas No. | 1173671-63-0 |
Relative Density. | 1.38 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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