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Y16
🥰Excellent
Catalog No. T3553Cas No. 429653-73-6
Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM.
Y16
🥰Excellent
Purity: 99.32%
Catalog No. T3553Cas No. 429653-73-6
Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $43 | In Stock | |
| 5 mg | $67 | In Stock | |
| 10 mg | $117 | In Stock | |
| 25 mg | $196 | In Stock | |
| 50 mg | $292 | In Stock | |
| 100 mg | $433 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $74 | In Stock |
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Purity:99.32%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM. |
| Targets&IC50 | LARG:76 nM (Kd) |
| In vitro | METHODS: MCF7 breast cells were treated with Y16 (5, 10, 30, 50 μM), and the effects of Y16 on growth, migration, and invasion, as well as mammosphere formation, breast cancer cell activity, and characteristics related to tumorigenic potential were studied. RESULTS Y16 significantly inhibited the growth, migration, and invasion of MCF7 breast cancer cells; Y16-treated MCF7 cells also produced smaller size and dose-dependently reduced mammary X-sphere numbers. [2] |
| Molecular Weight | 384.43 |
| Formula | C24H20N2O3 |
| Cas No. | 429653-73-6 |
| Smiles | Cc1cccc(COc2cccc(\C=C3/C(=O)NN(C3=O)c3ccccc3)c2)c1 |
| Relative Density. | 1.273 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (26.01 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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