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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $632 | 1-2 weeks | |
50 mg | $822 | 1-2 weeks | |
100 mg | $1,410 | 1-2 weeks |
Description | S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. |
Targets&IC50 | BCL2:1.3 nM (ki), BCL2:3.9 nM (kd), BCL-XL:520 nM (ki), BCL-XL:186 nM (kd)(ki) |
In vitro | S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death. |
In vivo | S55746 is a highly efficacious and well-tolerated BCL-2 inhibitor, orally active even at doses up to 300 mg/kg. In RS4 and Toledo models, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in a time- and dose-dependent manner. |
Alias | BLC201 (hydrochloride) |
Molecular Weight | 747.28 |
Formula | C43H43ClN4O6 |
Cas No. | 1448525-91-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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