Shopping Cart
- Remove All
Your shopping cart is currently empty
S55746 hydrochloride
😃Good
Catalog No. T12824Cas No. 1448525-91-4
Alias BLC201 (hydrochloride)
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
S55746 hydrochloride
😃Good
Catalog No. T12824Alias BLC201 (hydrochloride)Cas No. 1448525-91-4
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $632 | 1-2 weeks | |
| 50 mg | $822 | 1-2 weeks | |
| 100 mg | $1,410 | 1-2 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "S55746 hydrochloride"
Navitoclax
Cited
ABT-263
T2101923564-51-6
Navitoclax (ABT-263) is a potent oral Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM), demonstrating antitumor activity and inducing apoptosis.
- $41
Size
QTY
CitedVenetoclax Cited
GDC-0199, ABT-199, ABT199, ABT 199
T21191257044-40-8
Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces autophagy and apoptosis.
- $48
Size
QTY
Cited(S)-(+)-Ibuprofen
Dexibuprofen, (S)-Ibuprofen
T044851146-56-6
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
- $35
Size
QTY
Lisaftoclax
Bcl-2/Bcl-xl inhibitor 1, APG-2575
T104832180923-05-9
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of leukemia cells.
- $187
Size
QTY
Gossypol
Pogosin, NSC 56817, BL 193
T6518303-45-7
Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
- $35
Size
QTY
Triacetylresveratrol
Acetyl-trans-resveratrol
T566842206-94-0
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.
- $68
Size
QTY
Diphenyl disulfide
Phenyl disulfide
T37518882-33-7
Diphenyl disulfide (Phenyl disulfide) shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax protein hydrolysis activation and concomitant autophagy.Diphenyl disulfide inhibits cell proliferation and viability and reduces colony formation in a dose-dependent manner. Diphenyl disulfide can be used to treat breast cancer.
- $30
Size
QTY
Allethrin
T25049584-79-2
Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent.
- $30
Size
QTY
Gossypol (acetic acid) Cited
Pogosin, Gossypol acetic acid, AT101, (±)-Gossypol-acetic acid
T273012542-36-8
Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.
- $30
Size
QTY
Cited(E)-Ferulic acid
trans-Ferulic acid, (E)-Coniferic acid
T5679537-98-4
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin.t(E)-Ferulic acid exert both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
- $34
Size
QTY
Docetaxel trihydrate
RP-56976 (Trihydrate), RP56976 (NSC 628503) Trihydrate
T0186148408-66-6
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor including breast and lung cancer. Therapy with docetaxel has been associated with a low rate of serum enzyme elevations and rarely to instances of acute hepatic necrosis generally due to severe hypersensitivity reactions or sepsis.
- $46
Size
QTY
Sonrotoclax TFA
Sonrotoclax TFA(2383086-06-2 Free base), BGB 11417 TFA
T74637L
Sonrotoclax TFA is an orally available and highly potent and selective Bcl-2 inhibitor of WT and G101V mutants with antitumor activity for the study of hematologic malignancies.
Inquiry
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. |
| Targets&IC50 | BCL-XL:186 nM (kd)(ki), BCL-XL:520 nM (ki), BCL2:1.3 nM (ki), BCL2:3.9 nM (kd) |
| In vitro | S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death. |
| In vivo | S55746 is a highly efficacious and well-tolerated BCL-2 inhibitor, orally active even at doses up to 300 mg/kg. In RS4 and Toledo models, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in a time- and dose-dependent manner. |
| Alias | BLC201 (hydrochloride) |
| Molecular Weight | 747.28 |
| Formula | C43H43ClN4O6 |
| Cas No. | 1448525-91-4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy S55746 hydrochloride | purchase S55746 hydrochloride | S55746 hydrochloride cost | order S55746 hydrochloride | S55746 hydrochloride chemical structure | S55746 hydrochloride in vivo | S55746 hydrochloride in vitro | S55746 hydrochloride formula | S55746 hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.