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SGC-iMLLT

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SGC-iMLLT

Catalog No. T12886Cas No. 2255338-25-9

SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).

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Pack Size	Price	Availability	Quantity
2 mg	$46	5 days

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Product Introduction

Bioactivity

Description	SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
In vivo	After 60 min, SGC-iMLLT shows moderate metabolic resistance with t1/2 of 53 min and 48?% remaining, and the primary process for metabolism is N demethylation.

Chemical Properties

Molecular Weight	388.47
Formula	C22H24N6O
Cas No.	2255338-25-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 83.33 mg/mL (214.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5742 mL	12.8710 mL	25.7420 mL	128.7101 mL
5 mM	0.5148 mL	2.5742 mL	5.1484 mL	25.7420 mL
10 mM	0.2574 mL	1.2871 mL	2.5742 mL	12.8710 mL
20 mM	0.1287 mL	0.6436 mL	1.2871 mL	6.4355 mL
50 mM	0.0515 mL	0.2574 mL	0.5148 mL	2.5742 mL
100 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc