Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM).
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 46.00 |
Description | SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular target engagement of MLLT1(Kd = 0.129 μM) and MLLT3(Kd = 0.077 μM). |
Targets&IC50 | MLLT1 YD:0.129 μM(Kd), MLLT1 YD:0.26 μM , MLLT3 YD:0.077 μM(Kd) |
In vivo | After 60 min, SGC-iMLLT shows moderate metabolic resistance with t1/2 of 53 min and 48?% remaining, and the primary process for metabolism is N demethylation. |
Molecular Weight | 388.47 |
Formula | C22H24N6O |
CAS No. | 2255338-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 83.33 mg/mL (214.51 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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SGC-iMLLT 2255338-25-9 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibit Epigenetic Reader Domain SGC iMLLT SGCiMLLT inhibitor