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SS-208

Catalog No. T16936 CAS 2245942-72-5

SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.

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SS-208, CAS 2245942-72-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 112.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00

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Purity: 99.07%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
Targets&IC50	HDAC6:12 nM, HDAC8:1.23 μM, HDAC1:1.39 μM, HDAC11:5.12 μM, HDAC5:6.91 μM, HDAC7:8.34 μM
In vivo	In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth[1].

Molecular Weight	344.15
Formula	C13H11Cl2N3O4
CAS No.	2245942-72-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (290.6 mM), Sonification is recommended.

References and Literature

1. Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library NF-κB Signaling Compound Library Chromatin Modification Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Histone Modification Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

BRD4097 7,4'-Dihydroxyflavone HDAC6-IN-21 Sulforaphane PRO-HD2 SW-100 BEBT-908 2-hexyl-4-Pentynoic Acid

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SS-208 2245942-72-5 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC SS 208 SS208 inhibitor inhibit

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