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Soyasaponin Aa

Catalog No. TN2228 CAS 117230-33-8

Synonyms: 大豆皂苷 AA, 大豆皂苷Aa

Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipocytes.

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Soyasaponin Aa, CAS 117230-33-8

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Purity: 98%

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Description

In vitro

Soyasaponin Aa and soyasaponin Ab dose-dependently inhibited the accumulation of lipids and the expression of adiponectin, adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c, adipocyte fatty acid-binding protein 2, fatty acid synthase, and resistin in 3T3-L1 adipocytes. In addition, Soyasaponin Aa and soyasaponin Ab suppressed the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in HEK 293T cells. Furthermore, we confirmed that the expression of PPARγ and of CCAAT-enhancer-binding protein α± (C/EBPα±) was suppressed at both the mRNA and protein levels in 3T3-L1 adipocytes by treatment with Soyasaponin Aa and soyasaponin Ab.

Synonyms	大豆皂苷 AA, 大豆皂苷Aa
Molecular Weight	1365.473
Formula	C64H100O31
CAS No.	117230-33-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ.Phytother Res. 2015 Feb;29(2):281-7.

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Keywords

Soyasaponin Aa 117230-33-8 DNA损伤和修复代谢 PPAR Inhibitor inhibitor inhibit

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