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Soyasaponin Aa

Soyasaponin Aa
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipocytes.
Catalog No. TN2228Cas No. 117230-33-8

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Soyasaponin Aa

Catalog No. TN2228Cas No. 117230-33-8

Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipocytes.
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10 mg$220Backorder
1 mL x 10 mM (in DMSO)$350Backorder
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Product Introduction

Bioactivity
Description
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo
In vitro
Soyasaponin Aa and soyasaponin Ab dose-dependently inhibited the accumulation of lipids and the expression of adiponectin, adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c, adipocyte fatty acid-binding protein 2, fatty acid synthase, and resistin in 3T3-L1 adipocytes. In addition, Soyasaponin Aa and soyasaponin Ab suppressed the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in HEK 293T cells. Furthermore, we confirmed that the expression of PPARγ and of CCAAT-enhancer-binding protein α± (C/EBPα±) was suppressed at both the mRNA and protein levels in 3T3-L1 adipocytes by treatment with Soyasaponin Aa and soyasaponin Ab.
Chemical Properties
Molecular Weight1365.473
FormulaC64H100O31
Cas No.117230-33-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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