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Stylopine hydrochloride

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Purity:99.34%

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COA HNMR HPLC

Stylopine hydrochloride

Catalog No. T5807Cas No. 96087-21-7

Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.

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Pack Size	Price	Availability
1 mg	$72	In Stock
5 mg	$155	In Stock
10 mg	$247	In Stock
25 mg	$418	In Stock
50 mg	$596	In Stock
100 mg	$863	In Stock

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Product Introduction

Bioactivity

Description

Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.

In vitro

Stylopine is a major component of the leaf of Chelidonium majus L. (Papaveraceae), which has been used for the removal of warts, papillomas and condylomas, as well as the treatment of liver disease, in oriental countries.?Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.?The levels of inducible nitric oxide synthase (iNOS) and COX-2 protein expressions were markedly suppressed by stylopine in a concentration dependent manner.?Suggest that stylopine suppress the NO and PGE2 production in macrophages by inhibiting the iNOS and COX-2 expressions.?These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus.

Chemical Properties

Molecular Weight	359.8
Formula	C19H18ClNO4
Cas No.	96087-21-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.89 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7793 mL	13.8966 mL	27.7932 mL	138.9661 mL
5 mM	0.5559 mL	2.7793 mL	5.5586 mL	27.7932 mL
10 mM	0.2779 mL	1.3897 mL	2.7793 mL	13.8966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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